Self-reporting
biological nanosystems to study and control bio-molecular mechanisms
on the single molecule level 
BIOSCOPE will pioneer the development of new leading
edge nano-scale research tools and methodologies that will allow
unprecedented insight into bio-molecular mechanisms at biological
interfaces on the molecular scale. BIOSCOPE will adopt a new strategy
as it will consider the biomolecular system itself as a part of
the nano-scopic instrument, which in various ways reports to the
out-side world about its current local state. Thereby it will be
possible to study the local effects on the molecular level when
e.g. a protein interacts with a biomembrane surface or when a lipase
interacts with a lipid surface. The knowledge-base provided by BIOSCOPE
will allow researchers and industry to move from design of biomolecular
systems based on end-state global properties, which is just one,
some times distant, consequence of the true biomolecular mechanism.
As a unifying end-goal
BIOSCOPE design and test a preorganized nanosystem consisting of
several components with properties superior to the simple sum of
the individual components. This will be based on the fundamental
understanding of biomolecular mechanisms on a single molecule scale.
These “nano-machines” will have superior enzyme activity
compared to traditional means of immobilisation and will also allow
for controlling and switching on and off the enzyme activity
This STREP-project is getting financial support by the EU under
contract NMP4-CT-2003-505211 
| Co-ordinator: |
Tommy
Nylander, Physical Chemistry 1, Lund University,
PO Box 124, SE-221 00 Lund, Sweden.
Tommy.Nylander@fkem1.lu.se
Phone: +46-46-222 81 58, Fax: +46 46 222 44 13
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| Administrator: |
Birgit
Johansson, Applied Microbiology, Lund University,
PO Box 124, SE-221 00 Lund, Sweden.
Birgit.Johansson@tmb.lth.se
Phone: +46 46 222 83 25 Fax: +46 46 222 42 03 |
Publisher: Tommy.Nylander@fkem1.lu.se
Webmaster: Johan.Reimer@fkem1.lu.se
|
